There are six matches, one more than the other Duels expansions, with preconstructed decks against a series of computer-controlled opponents. Decks start at 40 cards, with 5 added each match for a total of 60 for the fifth and sixth matches.
The first match of the campaign has the player, representing Jace with a monoblue deck, facing a 40-card Werewolftypal deck.
“
Among Innistrad’s dark mountains, Jace Beleren begins his search in the one place on the plane that he knows—the home of his ally, Liliana Vess. But his path is fraught with danger, and Jace soon finds a cold welcome at the hands of a pack of werewolves.[2]
Jace implores Liliana to help him unravel the mystery. She rebuffs him, far more concerned with her pursuits of the demons that still held power over her and of the Chain Veil. She points him to Sorin’s home at Markov Manor, but she offers no other aid.[2]
”
Second mission
The second match of the campaign is against a 45-card Vampiretypal deck.
“
As he reaches Markov Manor in search of Sorin, Jace comes across a bizarre sight. The manor has been twisted into a gravity-defying pattern of floating stonework. Towers, halls, and buttresses hang at impossible angles around the sundered core of the building.[2]
Inside the manor, Jace finds no sign of Sorin, but he instead discovers the ghastly remains of the Markov bloodline embedded in the stone walls. Upon closer investigation, he locates a vital clue: a tattered journal filled with records of the recent happenings on Innistrad.[2]
”
Third mission
The third match of the campaign is against a 50-card typalZombie deck.
“
The entries in the journal lead Jace to the coast of Nephalia. Here, too, the ground has been warped into a strange formation rising from the sea. Hordes of zombies assist with construction, while dark shapes wheel overhead, drawn like moths to flame. Jace ventures down to the water’s edge to investigate.[2]
The ghouls claw at Jace, but this provides little information about the stone edifice before him. The sounds of frenzied wings overhead turn his gaze skyward. Angels. He’s seen them before in the journal’s entries. He follows the angels and the journal’s clues onward toward the town of Thraben.[2]
”
Fourth mission
The fourth match of the campaign is against a 55-card white weenie deck with an Equipment focus.
“
The final pages of the mysterious journal lead Jace to the doors of the foreboding Thraben Cathedral. The ground is broken, and the once proud, gleaming spires are warped and twisted. The townspeople and cathars of Thraben swarm around Jace. Their paranoid suspicions quickly give way to violence.[2]
Inside Thraben’s cavernous cathedral, Jace spies a pale, slight figure wreathed by floating scrolls. She pores over one of the strange, warped formations. She suddenly looks up, startled from her investigation. She is the moonfolk scholar Tamiyo, author of the mysterious journal that fell into Jace’s hands. As Jace approaches, a long shadow eclipses the light overhead. Suddenly, he is overwhelmed by vertigo and the raw, metallic smell of blood.[2]
”
Fifth mission
The final match of the campaign has the player take on the role of the PlaneswalkerTamiyo. Jace's role in this partnership is represented by the inclusion of Jace, Unraveler of Secrets in the 60-card deck. The opponent is the ArchangelAvacyn, with a monowhite deck.
“
The archangel Avacyn, former protector of Innistrad, descends into the cathedral in a flurry of bloody wings, leaving a wake of fiery destruction behind her. Avacyn’s mind is a maze of frenzied turbulence that sends the telepath Jace reeling. Tamiyo runs to his aid, though she too is struggling through the archangel’s madness.[2]
Just as Jace and Tamiyo believe they have managed to contain Avacyn, the archangel unleashes the full force of her fury upon the pair. The cathedral crumbles around them, and the Planeswalkers are knocked to the ground.[2]
”
Final mission
The final match of the campaign has the player take on the role of Sorin Markov with a Vampiretypal deck. Avacyn's deck is now .
“
Avacyn’s madness envelops Jace and Tamiyo, and the two are helpless under her thrall. The archangel raises her spear, but a sudden crash of shattering glass turns their attention upward to Sorin Markov’s arrival. The vampire Planeswalker casts his gaze in quiet fury to his beloved creation and guardian, the archangel Avacyn.[2]
Many years after creating Avacyn to maintain the balance between humans and the supernatural, Sorin is forced to unmake his corrupted guardian. Head bowed with painful regret, he looks away as he dissipates his progeny into an ashen cloud. With Avacyn’s destruction, the last of Sorin’s magical protections woven over Innistrad is broken.[2]