Lobotomy

Lobotomy refers to the act of exiling all (or any) copies of a card generally from target player's hand, library and graveyard. It alludes to the effect of its namesake, the Tempest card Lobotomy.

Lobotomy effects are primary centered in black—flavored as permanently messing with people's minds. Blue also used to be getting a decent amount, but nowadays it is solely to be found in black. Urza's Destiny had a lobotomy cycle that was reprinted in Betrayers of Kamigawa.

The most famous cards are Extirpate and Surgical Extraction.

Last Updated for Modern Horizons 3

Lobotomy cards are

Name	Cost	Original Set	What being lobotomized
Counterbore		Shadowmoor	Lobotomizes a countered spell.
Cranial Extraction		Champions of Kamigawa	Lobotomizes a nonland card of chosen card name.
Crumble to Dust		Battle for Zendikar	Lobotomizes a nonbasic land.
Deicide		Journey into Nyx	Lobotomizes an enchantment if it's also a God.
Dispossess		Amonkhet	Lobotomizes an artifact of chosen card name.
Eradicate		Urza's Destiny	Lobotomizes a nonblack creature.
Extirpate		Planar Chaos	Lobotomizes a chosen card, other than a basic land, from a graveyard.
Haunting Echoes		Odyssey	Lobotomizes all cards, others than a basic land, from a graveyard.
Infinite Obliteration		Magic Origins	Lobotomizes a creature of chosen card name.
Invasive Surgery		Shadows over Innistrad	Lobotomizes a countered sorcery spell if the player has enabled Delirium.
Lobotomy		Tempest	Lobotomizes a chosen card, other than a basic land, from a hand.
Lost Legacy		Kaladesh	Lobotomizes a nonartifact, nonland card of chosen card name.
Memoricide		Scars of Mirrodin	Lobotomizes a nonland card of chosen card name.
Necromentia		Core Set 2021	Lobotomizes a card other than a basic land of chosen card name.
Pick the Brain		Shadows over Innistrad	Lobotomizes a chosen nonland card from a hand if the player has enabled Delirium.
Quash		Urza's Destiny	Lobotomizes a countered instant or sorcery spell.
Reap Intellect		Dragon's Maze	Lobotomizes chosen up to X nonland cards from a hand.
Scour		Urza's Destiny	Lobotomizes an enchantment.
Shimian Specter		Future Sight	Creature that lobotomizes a chosen nonland card from a hand when deals combat damage to that hand's player.
Slaughter Games		Return to Ravnica	Lobotomizes a nonland card of chosen card name.
Sowing Salt		Urza's Destiny	Lobotomizes a nonbasic land.
Splinter		Urza's Destiny	Lobotomizes an artifact.
Stain the Mind		Magic 2015	Lobotomizes a nonland card of chosen card name.
Surgical Extraction		New Phyrexia	Lobotomizes a chosen card, other than a basic land, from a graveyard.
Talent Exam		Strixhaven: School of Mages	Lobotomizes a countered target or instant spell.
Thought Hemorrhage		Alara Reborn	Lobotomizes a nonland card of chosen card name.
Unmoored Ego		Guilds of Ravnica	Lobotomizes up to 4 copies of any card with chosen card name.

Silver-bordered

Name	Cost	Original Set	What being lobotomized
Look at Me, I'm the DCI		Unglued	Lobotomizes a card of chosen card name to all players (including their sideboards and the battlefield). The exiled cards remain exiled until the match ends.